In vivo studies in healthy nonsmoking men and mice with experimentally induced atherosclerosis (hardening of the arteries) concluded that pomegranate juice (Punica granatum)
had potent antiatherogenic effects, possibly due its antioxidant activity. In the men, consumption of pomegranate juice decreased the susceptibility of low-density lipoprotein (LDL) cholesterol to aggregation and retention, and increased the activity of serum paraoxonase (a naturally occurring antioxidant) by 20%. In mice, pomegranate juice reduced oxidation of LDL by 90%. In addition, pomegranate juice shrank atherosclerotic lesions in the mice by 44%, compared with control mice.
resource: Aviram M, Dornfeld L, Rosenblat M, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. American Journal of Clinical Nutrition 2000; 71: 1062-1076.
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